As Chair of Digital Health & Machine Learning at the Hasso Plattner Institute, Lippert is exploring the theory of machine learning and artificial intelligence, as well as novel applications in medicine and genomics. The focus is on advancing the capabilities to predict personal health risks and supporting the personalized prevention of health issues and diseases, by analyzing data from medical health records, imaging, and sequencing. Lippert has made important contributions to confounder correction in genomic association studies. Lippert studied bioinformatics from 2001–2008 in Munich and went on to earn his doctorate at the Max Planck Institutes for Intelligent Systems and for Developmental Biology in Tübingen on genome-associated studies. In 2012 he accepted a position in the US at Microsoft Research and subsequently carried out work at Human Longevity, Inc., a digital health venture founded by J. Craig Venter. In 2017 Lippert returned to Germany to head the research group "Statistical Genomics" at the Max Delbrück Center for Molecular Medicine in Berlin.